Well Buffett is 90 years old, so there's one example of a lifetime of 20% CAGR.
Both of them have been underperforming in the last decade or so. Medallion is still radically outperforming, however.
Based on what I see from quant prop trader friends of mine in the Chicago area, if Medallion was an order of magnitude smaller they could probably juice their returns up to 150-300% pretty reliably.