IE: I'm watching The Crown right now. I've been "spoiled" on the outcome of the show through simple history and cultural knowledge (I'm Canadian). It doesn't make the show any less enjoyable when I know that Diana is going to die, or that Mountbatten was killed by the IRA.
J. Michael Straczinski (Babylon 5) said he likes to tell people what's going to happen, but he doesn't tell you the context. This lets him put in prophecy as a story element.
Other times the story is really about discovery. You can guess that Harry Potter will bring about Voldemort's demise in book one, but the series is about the process of Harry becoming Harry, so it's not really possible to give away any spoilers because you have to explain too much.
I always wanted to write a story about a bunch of people in a lab, playing god. In this universe there would be no rings of hell, the reader would also know there wasn't, but I think it would still grip the reader. Like an inverse hero's journey.