The issue that immediately came to mind was that if you change the kerning settings, then you can't input em dashes as --- anymore. See, for example, this Tex.SE question:
https://tex.stackexchange.com/questions/315822/unwanted-kern....
But after a while I remembered the more fundamental point that bothered me:
> one might add that it's not just microtype that doesn't offer optical kerning -- it's structural limitations in TeX's typesetting that prevent it. To TeX, each glyph is contained inside a (I guess: black) box. TeX knows the outer dimensions of those boxes, but has no clue (and doesn't care) about what the glyph looks like that's inside it.
https://tex.stackexchange.com/questions/139926/optical-kerni...
And this led to bad spacing for hyphens, which led to me experimenting with manual kerning, which led to the issue that I recalled first.
Also, I am not really convinced of the merits of Vim for LaTeX. Most of my time writing is spent revising, which requires a lot of "random access edits," and I'm at least twice as fast at jumping to arbitrary locations on screen using a mouse as I am with vim (even with the usual tricks).
(I tend to think of vim as something that was purpose-built for programming in C and with usefulness inversely proportional to how far a given task is from that purpose. While I realize that's not entirely accurate, I've found it a good heuristic. Programming: vim works decently for me. General purpose writing: not so much.)
Further, the ability to control-click .pdfs and skip to the corresponding place in the .tex file, and vice versa, is an amazing convenience. I understand that there are technically ways to do this in vim, but then at that point I'm using the mouse a ton anyway and I don't really see the point of vim (which is usually proposed to be "hands don't go off keyboard = write faster" in my experience).
So, yes, I could survive if forced to use vim. I just wouldn't like it.
Given this, and given I feel I'm much more willing to experiment with these things than the average person writing papers in the physical sciences. I can't even imagine how the conversation would go if I tried to tell my 72-year-old advisor that TeXShop's not going to work anymore because he updated his computer and it's time to get friendly with the command line. These people want to do science, they don't want to learn vim shortcuts.