1. Avoiding Venezuelan hyper-inflation - it is a use-case, but doesn't really apply to the United States for example.
2. Store of value - volatility is way too high and there are much better alternatives (Treasury bonds)
3. Evading capital controls - it is a use-case, but not really applicable to most citizens in the US, and is unlikely to be applicable in the future.
4. Settlement layer for banks - banks already have a settlement layer that works for them.
The downsides of a decentralized system vs. a centralized system are an increased cost (in energy, computation, time, money, etc.) of transaction. So what justifies the cost?