I'm working on a few game concepts and made the decision to solely use the EGA pallet. It has to be one of the worst pallets out there, but when done well the results can be astonishing. You have to use dithering and you have to use some unusual colors (cyan and magenta come to mind). This creates a very unique, nostalgic feel that only EGA can produce. I also love adding interesting technical constraints to my game ideas.
"The enemy of art is the absence of limitations." -- Orson Welles