Tailwind brings with it the same issues that css-in-js does: the inability to just reload css curing the development cycle. When working with css (or a language that complies to css), any changes to the style are pushed to the browser without a page refresh. With tailwind and css-in-js, changes to style require changes to js/html and therefore require an entire page reload which both slows down my feedback loop and breaks any state I had established in my test app.