According to a web page I found from 5-minute googling[1]:
Depth of Field[mm] = (2 * u^2 * N * c )/ f^2
where:
u = distance to object[mm], N = f number(focal length divided by effective aperture diameter), c = diameter of acceptable circle of confusion[mm], f = focal length[mm]
Assume Sony A7M4 with Milvus 2/100: let u, N, c, f = (160mm, f/22, 4um, 100mm): DoF = 0.396mm ~ 1/3rd of a penny thick
The answer is no, not possible without focus stacking. But focus stacking is a SLR technique anyway, so the part that he's flexing his fancy camera a bit is true.
1: https://damienfournier.co/dof-the-simplified-formula-to-unde...