Through the period I'd experienced some significant lows that all met different criteria - extended depression, severe self harm and mutilation, social difficulties, drugs, alcohols, other unsavoury behaviour (not quite hookers and blow but close enough). Most of the chemical strategies weren't effective, or it was easy enough to discontinue them them shop around for something else a few weeks later.
In the end, I think I reached a point where I was genuine about change and engaged with a psychologist, and within a couple of months the outcomes were very apparent, and positive. Not saying its a good measure of anything either way, just a demonstration of another scenario I suppose.