In Redshift columns are stored in blocks. You want to fit roughly the same number of column values per block across all your columns. But if you have one column where a small number of values can fit in a block, the rest of the columns end up leaving most of the block space unused. The result is wasted disk space and poor query performance.
This Postgres extension has similar-sounding storage ideas with stripes, but it’s not clear to me if it suffers from the same issue.
My first test to vet this would be a table with 50 columns of ints and one column of md5 hashes stored as varchar.