Thanks for the datapoint. I've been following https://github.com/NixOS/nixpkgs/issues/102547 and considering trying it out for a while.
Did you just set services.pipewire.pulse.enable=true?
https://search.nixos.org/options?channel=unstable&show=servi...
My major concern is that I use PulseEffects as a key component of my setup so I'll need to check if that works well with PipeWire. But the only way to be sure is to try it!