Transgender issues are political when the government forces you to use made up terms like Xe/Xim or they/their instead of him/her to appease the mentally ill at the risk of being fined or jailed.
All words are made up and no one is going to fine you or jail you for being a jerk.
Canada, The UK, & New York City among others have considered legislation making misgendering illegal.
You aren't a jerk if you refuse to call someone a made up pronoun. If a she wants to be called a he, fine. If you want to be a benegender xyzbbq xe/xir, no.