As an example, my startup, Bractlet (bractlet.com), uses detailed, physics-based energy simulation (aka "digital energy twin") technology as a tool to optimize HVAC design and controls in large commercial buildings. I'm sure efficacy varies widely by domain, but it's worked extremely well for us so far; we typically help our customers save about 20-30% on their energy expenditures annually, and the digital twin is the bedrock of our approach.