Suppose I want to send a mission to land on the moon at a site not on the orbital plane of the gateway station. For an all in one mission this is no problem, I can match my Earth launch plane and transfer plane to line up with the destination. With a gateway station the lander has to do two plane change burns, on on landing and again on ascent back to the gateway. If you play KSP you know just how expensive plane change manoeuvres can be.
ISU is a great opportunity for sure, but we don’t have it yet. That would be a great reason for building a way station and a great reason for going to it on other missions. But without that reason what’s the point?