So Having a launch vehicle that does a rendevous with a LEO space station, then transfer the astronauts to a vehicle that is optimized just for the function of shuttling back and forth between an Earth space station and a Lunar space station, then have them board another craft that is optimized for landing on the Moon and taking off again, using minimal fuel because it doesn't need to carry the weight of the other components..
It makes designing a mission a lot more complex but at the savings of a lot of components and fuel, makes a lot more reusable components as well. Then when you add the ability to refuel in orbit by capturing asteroids, it really pays off.