I really hope the integration with QubesOS[1] will be completed in the near future. It will allow to run suspicious legacy Windows software without any hassle.
I think that for the long term, Wine is a superior solution, as it can use all the nice modern features of Linux kernel, and can easily co-exist with modern aoftware. The only feature that ReactOS has and Wine does not is windows device drivers - and QusesOS does not need those.