Outcomes for who? The individual or the population? Seriously. Ask a doctor and they would probably agree that, for a particular patient, having access to legal safe alternatives is a good thing. But ask them about drugs as a whole, for the entire population, and the answer will always be "less is better but zero is best." Stemming the supply will damage current users, but illegality also suppresses uptake by new users.
Opioids are different than pot. LSD is different than rohypnol. Cocaine is not the same as ketamine. Balling all "drugs" into one category and declaring them legal for traffic and sale is a horrible idea. I don't want to see GHB to ever be sold or transported openly.