Here's something I can only speculate on with the cold chain.

I have mentioned it elsewhere on HN, but I've handle dry ice and liquid nitrogen quite a bit, first in college and then just later for fun. Several years back, I noticed a very large price hike in dry ice, as well as a drop in availability (less available in my city, vanishing from small towns). I was told by someone in my supply chain that federal regulations around dry ice had changed, resulting in only a few players being left in the game and of course the price going up.

I wonder if now, a decade or so later, the law of unindented consequences has reared its often invisible head.