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I've found cli53 to be quite useful for Route53 https://github.com/barnybug/cli53

Also, ylastic.com is awesome if you want a GUI for many of AWS functions. It's only US$ 25/month

We've also paid for an instance which does only redirects to a subdomain because of ELB limits. Now I'm on my way to work and I know what I'm going to do when I get there. This is so huge. :)

Absolutely and also, the ELB security group feature is neat as well. Can trust the X-Forwarded-For header now!

I've been using the route53 gem ( https://github.com/pcorliss/ruby_route_53 ). It's not a GUI and it's not perfect, but it's better than nothing.