One of my best memories from my career: I was sitting at my desk at 8pm "working" because I had "so much to do". When in reality I was just dreading going home. A coworker that I barely new dropped by my desk and said "Things aren't going well at home, are they? Me either." We proceeded to head across the street to a bar to share stories. It helped immensely at that time.
I make an effort to pay it forward. If you see someone in the office at all hours, especially when wfh is an option, odds are good things aren't going great for them. Even just a simple "How are things going with you?" over the water cooler can go a long ways.