Like I said, he talks about metabolic pathways, which are independent of dose, though not your body's current state of glycogen deficiency.

He also speaks to the effect of insulin resistance, and how the very rapid metabolism of fructose in the liver (7x faster than glucose) can lead to insulin resistance. Insulin spikes redirect calories eaten directly to fat, without them ever being metabolized into energy. As a result you gain fat and have less energy available, leaving you both fatter and hungrier.