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Well, there's that line, which is brilliant, and then there's the fact that he clearly runs on a 6502, soooooo.....

Futurama is full of obscure geek references, I wonder whether this is a jab at T2.

More of a tongue-in-cheek reference to the reoccurring joke that bender wants to kill all humans, except for his pet Fry.

You can indeed simulate a neural net on a 6502. Not enough nodes to model a T-800, but...