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Node uses V8, which does JIT compilation, while CPython is a straight bytecode interpreter. A better point of comparison would be PyPy

Are there any CPython vs PyPy benchmarks?

Okay according to their results: https://pybenchmarks.org/u64q/chartbox.php?s=eNptUtttAzEMW0l... PyPy seems to be twice as fast as CPython in these benchmarks. While this is indeed a noticeable achievement, it is still much slower than Node.