Some usb drives are much slower than a decent sd card. Also, the ultra has cooling issues.
However, there are usb3 nvme enclosures that are incredibly cheap, and blow both out of the water:
https://www.jeffgeerling.com/blog/2020/fastest-usb-storage-o...
For a build like the one in the article, I imagine something that puts two nvme sticks beside each other, sandwiched between every other rpi, with passive aluminum heat shields in the remainder of the spaces between the rpi’s. I bet it could be even denser (more pis and more storage) and quieter.
I wonder if space can be saved by making a heat shield heatsink that has a pi on both sides, and fins in the middle.
Super cool article.