In the latter case I'm not aware of a single service that uses seccomp to do this. The closest to a non WASM setup is either things like Firecracker or to enforce some sense of sandboxed language like JavaScript. Seccomp quite often plays a role in keeping those sandboxes safe, but it's generally not used to have people execute arbitrary binary blobs on SaaS.
Having people compile code to WASM to execute it in a sandbox is becoming quite widespread. Shopify is not the first company to do that.