Not on mine in the UI, you can pause for 7 days or set hours to reboot during (but you need X hours per day that it can reboot during) but not have it disabled perpetually.

I did via the registry, but I later discovered that these changes reverted after updating.

I now have my render box completely disconnected from the internet and I task it remotely.

You can make it not reboot with group policies, not commonly known though - most people try the registry stuff which doesn't seem to work consistently. Been running Win10 Pro for a couple years, never had a single unwanted reboot, once went nearly a year without doing a single update.

Specifically, in group policy:

Computer Configuration > Administrative Templates > Windows Components > Windows Update > "Configure Automatic Updates" and "No auto-restart with logged-on users for scheduled automatic update installations"