As with any tool, if you don't use it properly it can hurt you.
What about QMail and DJBDNS, from Dan Bernstein? Again, all C.
And the mother of all: the Linux kernel. Again, in C.
[1] https://github.com/jas502n/Redis-RCE
[2] https://www.qualys.com/2020/05/19/cve-2005-1513/remote-code-...
[3] https://web.archive.org/web/20190126114638/http://article.gm...
There was also a pure Rust Wayland binding that failed because Wayland assumes that you are using C semantics which made it hard to provide a safe interface for Rust that was also convenient.