Could someone explain the significance of these findings?
It's not remotely my area of expertise, and I'm having trouble seeing if/how this has any current or future clinical significance.
It's not remotely my area of expertise, and I'm having trouble seeing if/how this has any current or future clinical significance.
My interpretation is that your gut bacteria are vital for metabolizing Vitamin D and that you can take a lot of supplements but if your gut aint right it won't help.
Slightly related: I keep trying to identifty the recent report that essentially demonstrated a big calculation error in our societal wisdom regarding Vitamin D amounts - and that we need a LOT more than most people think. 2,000 - 5,000 IUD is like a fraction of it.
Edit, found it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/
A statistical error in the estimation of the recommended dietary allowance
(RDA) for vitamin D was recently discovered; in a correct analysis of the data
used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5%
of individuals to achieve values ≥50 nmol/L.
....we call all responsible public health authorities to consider designating
as the recommended dietary allowance (i.e., the average daily level of intake
sufficient to meet the nutrient requirements of nearly all healthy people,
presuming minimal sun exposure) intake levels corresponding to those proposed
by the Endocrine Society Expert Committee (2011) as safe upper tolerable daily
intake doses for patients at risk for vitamin D deficiency (<50 nmol/L):
2000 IU for those <1 year of age,
4000 IU for those aged 1-18 years,
and 10 000 IU for those aged >18 years.
I have been taking 10,000 IU every night for a week or so - going to keep cruising on it for a while to see how I feel.
The way to know you're ok at your current dosage is to take a blood test, ideally at least twice a year (summer and winter) so you can make sure you're not overdosing.
I haven't had a blood test in many years, so currently I am only on 3000 IU. It's a big difference, in one week I have 21,000 IU and you have 70,000 IU, I am only taking 30% of the dose you are.
Get a blood test!
I don't think running diagnostics on a human should be this hard, we run diagnostics on our apps, computers, cars more often than ourselves. I wonder if people are working on making this process a lot easier (or if it's even possible, I have zero knowledge of the space).
Here are a few alternatives you can look into, mentioned in this discussion: https://news.ycombinator.com/item?id=15868143
[0]: https://www.privatemdlabs.com
[1]: http://www.directlabs.com/
[2]: https://www.walkinlab.com/
(I also dislike the limitations as I feel like people are more capable of helping themselves in a lot of these situations)
Google "LabCorps" near you.
You can walk in and get a basic metabolic panel in about 15 minutes, with results the next day or two, for about $50, without a doctor. I use them for frequent STI testing.
It seems like it’s just tough because you generally need a fair amount of blood for each test. We could lose some of the bureaucracy but it seems hard to get away from human phlebotomists and lab techs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/
While toxicity is a serious matter, the actual risk is generally overblown, since it requires truly heroic, sustained doses.
>The evidence is clear that vitamin D toxicity is one of the rarest medical conditions and is typically due to intentional or inadvertent intake of extremely high doses of vitamin D (usually in the range of 50,000-100,000 IU/d for months to years)
https://www.mayoclinicproceedings.org/article/S0025-6196(15)...
(For the record, I began taking 1-2k IU/day in March.)
This makes me wonder if there is a problem in my gut. I was on a 50k IU / week dose because of low vitamin D. It made no impact.
Being out in the sun, however, made a huge impact - so I get much more sunlight now and I'm fine. I wonder if the vitamin D issue correlates with largely indoor office work now vs farming of our ancestors and largely being outside.
Vitamin D stores in your body can take a long time to build up, but if you store too much it can be a major problem.
You should at least consider an at home vitamin D test, I found a few online(that i didn't order in the end) that were selling for around $50.
If you're determined to do this yourself you should periodically use those tests to help keep yourself safe.
Source: I'm not a doctor.
It would be better to take it at lunch: from what I have read a long time ago it might affect your sleep if you take it late.
You need to do blood tests. Don't take 10,000IU daily without consulting a doctor. The "generally considered safe" upper limit is 4000IU. You'll probably be fine with 2000IU. Too much Vitamin D can mess with your calcium and doses as low as 5000IU/daily over a few years have been reported to cause serious problems.