> I am here to tell you that the reason so much of the world seems incomprehensible is that it is incomprehensible.
This statement rubs me the wrong way, in a similar fashion to what you've pointed out. All of the world's systems and technologies haven't been able to be understood by one human for (most likely) a very long time now.
The world is incredibly complex, but at this point in history I can go and learn about pretty much all of it whenever I want. By definition that means it is very comprehensible. It just isn't practical for me to do so.
Modern scale as you've pointed out, and speed at which things are expected to happen to keep that modern scale going, are the bigger factors I think.