I would wait until replication in primates (human or non-human) before drinking ayahuasca to grow brain cells.
I would wait until replication in primates (human or non-human) before drinking ayahuasca to grow brain cells.
We know that DMT binds with sigma-1 receptors (S1R) which is known to promote neurogenesis, such as fluvoxamine (in addition to many other SSRIs) in humans; we further know that the medication causes neurogenesis in humans, as do other medications with S1R affinity[0].
We then know that DMT does as well, we then measure that neurogenesis is observed in mice due to the same exact mechanism as SSRI's (i.e. medications with S1R affinity) in humans.
Perhaps at some point we should realize deterministic action in the context of the mammalian brain over human exceptionalism.
I'd still like to see some human evidence of this effect to be fully convinced, but still that this story fits in this broader context does help convince me that this is likely true in humans.
Just saying because one of my classmates in art school barely survived jumping out of a five story building due to a bad trip.