Might actually be related to life extension through calorie restriction in this regard. This paper re calories restriction mentions:
> caloric restriction improves whole body energy efficiency by inducing the biogenesis of mitochondria that utilize less oxygen and produce less reactive oxygen species (ROS). https://journals.plos.org/plosmedicine/article?id=10.1371/jo...
Starving the body of oxygen might trigger some of the same genetic pathways as starving it of food, basically.