That depends what is your use case.

I use two 5TB 2.5 SMR drives in ZFS mirror:

https://vermaden.wordpress.com/2019/04/03/silent-fanless-fre...

These drives can slow down to 30-40 MB/s when filled to 80% or more but I use that storage over WiFi which is at most 11-12MB/s which means the SMR problem does not exist for me.

If I would be using that storage over LAN the 30-40 MB/s in 'WORST CASE' is also not bad considering that maximum real life LAN speed over gigabit network is about 80-90 MB/s.

Its also not possible to get non-SMR large 2.5 drives. I use 2.5 drives as they are silent and they need very small amount of power comparing to 3.5 drives.