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This doesn't replicate, AFAICS. The one in Phase I by Imperial College is instead self-replicating.

Did some more searching today and this one does in fact amplify just like the Imperial College one

Did it? Can you point me to the relevant paper? It's been a while since I read their phase 1 data.

https://www.sciencedirect.com/science/article/pii/S187962572...

See the section on COVID-19 near the end.

> Pfizer Inc. (New York, NY) in partnership with BioNtech (Germany) has also developed a saRNA prototype vaccine, although the details of this vector/formulation have not been disclosed yet.

AFAICS, this is not BNT162b2, which is the one that we are talking about. There are 3 other candidates, one of them is the self-amplifying one.

Looks like you are right! Thanks for the good news!

So will this be in significant quantity in my body for years?

I don’t know. Busy straining my biology knowledge trying to figure that out.

The paper seems to imply maybe not? https://www.sciencedirect.com/science/article/pii/S187962572...

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