I live in the bay area and everyone I know calls it "I-5". "Everyone I know" of course could be biased though as most of my circle did not grow up in California.
I moved to Northern California (Santa Clara County) in the late 80s and I still use the same monikers. If I take a trip to Big Sur, I tell folks I am going to take the 17 to PCH and drive down. Old habits die hard.
https://www.kcet.org/shows/lost-la/the-5-the-101-the-405-why...
— https://www.kcbx.org/post/how-you-refer-us-101-says-lot-abou...