The next big guy (let's not make the poor guy/girl follow someone else's legacy) can be anybody who is great in either of Design, Programming or Business and practically capable (if not 10X) in the other two.

If you are just a great hacker, you CANNOT be the next thing. If you are just a designer, you CANNOT be the next big thing. And likewise.

Assumption: You do not have a team/cofounder that/who compliments your skills totally and share the same vision.