I had the same issue, and it didn't respond to Inexium (PPI) but cleared up totally with Pantoprazole.
I had the same issue, and it didn't respond to Inexium (PPI) but cleared up totally with Pantoprazole.
The ranitidine, omeprazole, and pantoprazole are all intended to treat pain[1] from heartburn, and they've all worked at first and gradually lost effectiveness. (While still being mostly effective, just not totally effective.)
However, going without heartburn pain for weeks at a time has not helped my throat. When this didn't work, the gastroenterologist put a sensor down my throat for a day to record pH levels, and reported the results to me with "good news! You don't have heartburn!"
Of course, I do have heartburn. The response to "in that case, what does it mean that I have this burning chest pain after eating which is immediately relieved by tums?" was "well, some people are more sensitive to acid than others".
(I have many classic symptoms of acid reflux, including minor regurgitation of food after eating, "globus sensation" (feeling of a ball in the throat) when swallowing, and of course burning pain in the chest.)
But I continue the heartburn medication anyway, because heartburn hurts and I independently want to avoid it. :/
[1] Actually, they're intended to suppress the acid itself, not the pain you feel from exposure to it.