I once took too much acid and the hour I spent in the peak was too strong and took a lot out of me. By the time it passed, I felt ravenous hunger for the massive grapefruit I had in the fridge. About halfway through eating through it's succulent splendor, I had to set the fruit aside and lay down because I felt like I was peaking again.
This is why grapefruits are such a recurring element in Fear & Loathing.
Forgive me, I pictured your experience and it made me laugh. :-D
Yes, THC is also metabolized by the CYP3A4 enzyme that grapefruit inhibits
So, to be clear, you are saying that in this case the grapefruit would increase or decease the effect of the THC? In other words, to increase the effect of the cannabis, is it metabolites that we want to maximze, or the amount of unmetabolized free THC?
Yes, grapefruit would increase the effect, and you want to maximize the unmetabolized THC. (although the first metabolite 11-OH-THC is also active, the next metabolite THC-COOH isnt)
Myrcene helps THC cross the blood-brain barrier faster. It is found in over-ripe mango and as one of the terpenes in some varieties of cannabis.