Ok, maybe not an iteration then. But Sawyer drew inspiration from Raiload Tycoon and wanted an isometric version. Then it was natural marketing to publish Transport Tycoon with MicroProse. source: https://www.filfre.net/2020/10/transport-tycoon/

Sid Meier and Will Wright (Sim City) had the system simulators in 2D, and I wonder whether Sawyer influenced them with the isometric world from Transport Tycoon.

Railroad Tycoon and Railroad Tycoon 2 are two of my all time favourite games. Along with Sid Meier's Colonization, they are actually the only games that I've gone back to time after time for years.