I've used Tridactyl (as well as similar other plugins) in the past, but eventually I found myself having to disable it on a lot of websites due to poor interaction with web site keybindings.
The only website keybinding that really frustrates me is /, which many sites bind to their search feature. I don't understand why they do that. Don't web browsers already have page navigation features? Either the user is a mouse maid and can click the search field themselves, or they have a keyboard navigation tool such as Tridactyl and the binding just overrides the tool.
For the search functionality specifically, I guess it's possible to find a solution. The page-specific search shortcut will just focus a specific element on the page, and maybe that could be provided on a different shortcut in addition to /.