I develop hardware. At any given time I have 3 programmers, various charger cables, usb to serial cables, logic analyzers, a mouse, a spacemouse (for CAD), flash drives, 2 x label printer (strip and shipping) and various other stuff plugged into my 12 port hub. And I still have to switch them out due to lack of ports. And hubs don't play well with high speed USB3 based logic analyzers.

CIA agents with 16 FIDO keys.

This machine is clearly designed to straddle the DMZ in an infosec army. And/or Goldman Sachs, which is the same thing.

Surveillance or “self driving” demo gear on multiple webcams?

Phone farms? 20 random Android phones as physical emulators. More with hubs.

Testing USB flash drives? Flash drive factories use standard Windows boxes to test new drives and pre-load with bloatwares.

I could see this used for livestreams where you have a lot of cameras to connect. The 3 independent video outputs also make this great for a multi monitor setup.

https://wiki.debian.org/Multi_Seat_Debian_HOWTO with a bunch of USB3 docking stations: run an entire coffee-shop or class-room off one computer.

With active USB3 cables you can attach 20x 4K terminals, up to 10m away from the computer, easily.

USB flash drives are very reliable and should be used in raid 0 with this logic board for maximum raw size and speed. /s

I'd be interested to see all 20 fully loaded with HDDs/SSDs that support UASP, and see how well it holds up as a highly redundant Storage Server.

I have multiple mice and keyboards plugged in at once. This will do nicely.

All weird hardware recently seems to be for cryptominig. Probably for using a lot of USB miners.