You have to weigh the waste disposal and storage costs against the external costs of other fuel sources. What is the "cleanup cost" of carbon emissions from fossil fuels? Even wind power has a waste disposal cost; the blades are often made of toxic material and must be buried when they wear out.

The scary radioactivity of long lived isotopes can be dealt with via geological storage. There is plenty of rock underneath us that can be tunneled into. We can store basically limitless quantities of radioactive waste deep underground, forever.

And then there is reprocessing. France and other countries aggressively reprocess their spent fuel, freeing up new fuel without additional uranium mining. There are highly toxic biproducts from reprocessing that must be stored for a long time; however, these products are small in volume.