One of the things I would struggle with is progression.

In my current job I'm progressing quickly and have built good relationships with my colleagues. We can take a break and just turn around and chat for 10 minutes about random stuff. When everyone is working from home it's not like I could just call someone and chat to them because I don't know if they're busy or not. I can't build the same sort of relationships as I can in person.

I'm quite introverted in a way that I find it hard to go out of my way and make friends. But the longer I spend with people in person, the easier it is and I find that I'm able to get along with almost everyone I meet.

And as with most things, it's not really what you know, it's who you know. And knowing someone IRL is much better than knowing someone remote.