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Here is a condensed, blog-post version, based on that Robert Sapolsky's lecture. https://www.scienceme.com/the-biology-of-depression.php

Sapolsky himself struggles with depression, which he claims is genetic, IIRC. Not that I know anything, but I was struck that someone with his knowledge and intellect seemed to have given up attempting to treat it. He maintained psychological defenses that made me wonder whether he'd received adequate care.

I'm not sure where I heard this, but likely it's one of the following podcasts, which are worthwhile.

Sam Harris #91 - The Biology of Good and Evil https://samharris.org/podcasts/91-biology-good-evil/ YT version: https://www.youtube.com/watch?v=rLWzMH8psFU

Peter Attia #51 – Robert Sapolsky, Ph.D.: The pervasive effect of stress – is it killing you? https://peterattiamd.com/robertsapolsky/

Thankyou, I'm watching it now.