The thing is you could operate it under Windows (98) in protected mode, but then you lost statistics. How come? Well, Windows scheduling meant that the MCA only took data while it was allotted time slices, as a result the dead time of the whole setup increased, and you couldn't tell by how much.
Under real mode DOS it took advantage of DOS being almost an RTOS and the program running as a single task and you could be pretty confident about your data.
I don't think using adapters with this sort of cards is a good idea. It's not a matter of drivers, sometimes the old stuff simply doesn't work well when plugged in newer systems because everything has changed and you need to redesign everything. If the old stuff does the job, the OS being unsupported only becomes an insurmountable problem for the folks that consider using an unsupported OS some sort of crime in itself. Well, there's usually more than just an abstract computer being used in such circumstances.
So, yeah, I'm sure that USB-ISA adapter probably works with that old 3Com ethernet card or that Soundblaster card that 'definitely' sounds better than anything else, but a custom card with custom software and probably unknown tolerance to variations from 'real' ISA? Good luck with that.
My brother's company does IT stuff for the manufacturing sector. Very conservative. I've worked with a number of his customers to source exactly this sort of thing. Years ago they asked my thoughts on an Italian made cloth dying machine the size of a bus with a DOS PC controller and a minimally documented ISA controller. A mid 7-figure US$ setup; the company that built it is long gone. We found a shop that supplied new motherboards, modern (at the time...P3/P4 era I think) with ISA slots the vendor guaranteed it would be every bit as slow and weird as a PC/AT. Migrated everrything over, the company bought a stack of motherboard spares new, and I think they're still using them.
Now...you want a challenge? Migrating the proprietary, mostly undocumented software, all in Italian (we aren't native speakers...though my high school Latin occasionally helped) from an old ESDI disk to something, anything, else. That was much more interesting.