Read it but it left me curious how it may affect intersex people like XXY and found a better article [0]. So tldr, apparently number of X chromosomes affects cytokine production. "The lower secretion of inflammatory cytokines in women may protect them from an uncontrolled and potentially life-threatening immune response in cases of severe aggression such as sepsis, trauma or extensive burns throughout life."

[0]: https://www.frontiersin.org/articles/10.3389/fimmu.2019.0105...