As the lucky early adopter of gmail I got my last name only @gmail.com. It has been a blessing and a curse.

I have a boilerplate "you have the wrong address" email in multiple languages that I use to reply to the first email from real people. If they persist they then get added to my auto-reply "you have the wrong address" and delete rule.

For automated emails, I don't even bother trying to unsubscribe. They all get added to the delete blacklist rule.

Some of the more fun mistakes I have gotten have been multiple years worth of tax documents from New South Wales, Wine Tastings in South Africa, Church Choir concerts in Germany, and resumes for a receptionist in Colorado at a Gym.