Yes.
1. Trump is no longer an unknown.
2. Biden is far more popular than Clinton was at her peak.
3. Biden is male (which is sadly very relevant in US elections).
4. We are no longer in the biggest economic expansion in US history. We may be in a historic recession.
5. There is a pandemic that has killed 60x the number of Americans that died on 9/11, and it is no under control in the US at all.
6. Kamala Harris is not like Tim Kaine.
7. Lots of anti-Trump voters are afraid to be complacent this time.
8. Suburban women, true independent voters (those who dislike both candidates), and older Americans are either breaking for Biden or have substantially switched to Democratic support after going for Trump in 2016.
A better question would be: is anything the same this time around?