But the pilot requires more design compromises. The requirement to have a large canopy protruding from the fuselage for maximum visibility is a challenge to both building a stealthy aircraft and aerodynamics.
Also, currently the pilot and their circulatory system keeps aircraft from turning at more than ~9G (and then only for brief periods of time). Without a pilot, it would be possible to build aircraft with stunning maneuverability.
A better option would probably be to design drones that are less maneuverable. Sure more will be shot down. But that will lower the price so just manufacture more.
Another commenter said it first, but pretty much any set of reasoning that gets you to autonomous drones eventually leads to simply making guided missiles.
If we didn't have to care about those things, changing the existing infrastructure in an aircraft would be greatly simplified (not simple, but simplified).
High-G maneuvers are great for an in-close adversary moving relative to you. They don't do much against an adversary approaching at Mach 4. At that speed, while pulling 10G, you'll make less than a hundred foot change in your predicted position while the missile closes the last mile.
And keep in mind, the missile will be actively tracking you during this period.