If fact, huge projects are likely to suffer from using React, because virtual DOMs get out of hand and a lot of resources a wasted by building and rebuilding VDOM and looking for the changes.
Also, for some reason, React brings a lot of cargo-culting. Many don't stop to thing whether they should even if they can. They bring React, then they bring Redux, then all the rest is being dragged in and you get multi MB bundles for some truly trivial purposes. Of course, that's more on developers than on React, but it happens way to often. And for some reason just bringing React and Co. is not enough, it usually ends up in some imressive architecture astronautics. At the end you have a project that is big, but slow and still impossible to understand because the levels of indirection are off the charts.