We ended up with 2 python layers:

-- Boring code - Business logic, CRUD, management, security, ...: django

-- Perf: JWT services on another stack (GPU, Arrow streaming, ...)

So stuff is either Boring Code or Performance Code. Async is great b/c now Boring Code can now simply await Performance Code :) Boring Code gets predictability & general ecosystem, and Performance Code does wilder stuff where we don't worry about non-perf ecosystem stuff, just perf ecosystem oddballs. We've been systematically dropping node from our backend, where we tried to have it all, and IMO too much lift for most teams.