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> Statins will stop the production of CoQ10 by lowering FPPP production which is why they fail to help people with Heart Disease

I would like to know more about this. I've been on a statin for several years and feel like my energy has dropped through the floor in that time. I also feel like I have a 'statin hangover' when I wake up in the morning (I usually take it with my supper). This could all be correlation, and aside from cholesterol levels I haven't been diagnosed with heart disease. But I would like to know more, because I hate taking this stuff and really don't like the idea of being on it the rest of my life.

This is pretty much all you need to know:

https://ubiquinol.org/sites/default/files/statins.gif

The thinking on cholesterol and heart disease is changing rapidly and there really is no strong evidence high cholesterol before a heart attack leads to any bad outcomes. After a heart attack, statins are ok.

But like we see, side effects. My doc wanted me on them but they gave my mother horrible myopathy so I passed. My HDL was really low until I took out all plant oils and eat fats pretty much only from fish and olive oil. Now my HDL in mid range normal. This is becasue the omega 3 helps with reverse cholesterol transport.

But again, this is me and my genetics. We have Saami (Inuit) heritage which is why I think i need this diet.

> I am disabled with Anxiety and Mood Disorder and chronic fatigue/depression. Typical "Bipolar" presentation. It runs in my family on my mothers side.

That sounds awfully familiar. Would you be so kind to provide any starting point to begin research into this, including the supplement stuff you mentioned afterwards?

I would start by getting your full genome run, or at least get it from Ancestry. Then learn how to look at the low frequency SNPs. I am lucky as I live near UNC Chapel Hill that has several departments looking into this stuff.

The supplements came after I saw my genetics and from past anecdotal experiments. But maybe start by understanding the electron Transport chain. When I saw all the oxidative stress created there I began looking at the several pathways for the flow of O2- and H2O2. To me, mood disorders have their root in this flow being unobstructed.

Riboflavin ended up being big for me for several reasons.

Keep in mind, mood disorders are polygenic, may causes, so for you it might be something with Monoamines or what ever.

I wish doctors would get serious about testing for these deficiencies in people wit mood disorders...

Can you tell me which SNPs were relevant for you? Or are generally relevant for depression?

I checked https://www.snpedia.com/index.php/Depression but maybe you know better which SNPs are most important?

I got my genome and checked it using promethease, but 'sadly' I didnt get any major 'depression' hit; only minor SNPs which were correlated with 1.5x more probability to get depression

And I got no advice on which diet could help me :)

I'm in a similar situation. I've found that taking CoQ10 and NAD+ (e.g. Niagen or Elysium Basis) has been helpful.

Did you ever take lithium?

Yes, both carbonate and orate. The carbonate, well that flattened me out of course, but it did not make me feel as good as I do now. (Which is not that good but much much better.)

The ortate I took as an experiment wen I was more recently depressed and it made me hypomanic. This makes sense if you know Lithium inhibits IMPase and IPPase. And on the other side GSK-3.

It is only at high doses that you get the NMDA and GABA effects. Which is too high IMHO. I still rely on Klonopin now and then when I mess up. (No, I do not take it everyday and I take the lowest dose possible, so don't bother telling me how dangerous it is.)

Thank you for your answer.